Young researchers from the Medical University of Wrocław have investigated the effects of caffeine and caffeinated coffee on aluminium compounds and the development of Alzheimer’s disease. Their project proves that a ‘little black coffee’ neutralises the negative effects of aluminium on neurodegenerative processes.
The aim of the study was to assess the effects of caffeine and caffeinated coffee on the neurotoxicity of aluminium compounds. The young researchers used rat cultures of PC12 pheochromocytoma cells, which are used to analyse neurodegenerative processes, and aluminium maltol. Adding it served to induce the toxic effect of aluminium on the cells. PC12 were cultured in a medium (special liquid) containing caffeine compounds and soluble caffeinated coffee at three different concentrations (5, 80 and 320 µg/ml).
A test performed after 24 hours showed that the survival rate of PC12 cells was higher relative to the control when they were treated with a coffee solution with a caffeine concentration of 80 µg/ml (equivalent to a standard cup of coffee).