Scientists from the Center of New Technologies at the University of Warsaw (UW) and the Faculty of Physics at the University of Warsaw, under the supervision of Prof. Jacek Jemielity and Dr Joanna Kowalska, have developed a new efficient method of mRNA labeling that allows for detailed tracking of the fate and activity of this molecule in living cells, and even throughout the body. 

This discovery is reported in the latest edition of the Nucleic Acids Research journal. The research was co-financed by the Foundation for Polish Science under the TEAM grant from the funds under the Intelligent Development operational program.

The obtained results are important from the point of view of designing new mRNA-based therapies. They include anti-cancer vaccines (both preventive and curative), therapies for rare genetic diseases such as spinal muscular atrophy (SMA) or applications in regenerative medicine.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab867/6378437?searchresult=1