A paper by Dr Mateusz Siedlinski and Prof. Tomasz Guzik from the Faculty of Medicine at the Jagiellonian University (UJ) Collegium Medicum in Krakow has been published in the leading cardiology journal European Heart Journal. The study represents the first attempt to find causal links between high blood pressure and its important clinical complications affecting the brain, its structures and people’s cognitive functioning.
The researchers were able to identify, using genetic tools, specific brain parameters that are potentially affected by the effects of blood pressure changes in humans.
Of the nearly 4,000 parameters obtained by magnetic resonance imaging of the brain, more than 200 were altered by increased systolic blood pressure.
The analysis was conducted on large populations, such as the UK Biobank and the International Consortium for Blood Pressure, and additionally addressed questions about the relationship between blood pressure and cognitive functioning.
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