Researchers from the University of Silesia have developed an innovative, highly physically stable, amorphous pharmaceutical composition based on probucol and a method of its preparation. Probucol in combination with atorvastatin can be used for effective therapy of cardiovascular diseases, and its physically stable amorphous form will be more easily absorbed by the patient’s body.

Pharmaceuticals in amorphous form – unlike their crystalline counterparts – are characterized by much better solubility in water. In the case of amorphous substances, the risk of side effects that could occur as a result of excessive retention of undissolved drug in the villi of the small intestine is also reduced.

The authors of the invention are scientists from the Faculty of Exact and Technical Sciences: Prof. Marian Paluch, Dr Eng. Justyna Knapik-Kowalczuk and Dr Marzena Rams-Baron. The solution has been patented.

More: https://us.edu.pl/patent-ktory-pomoze-w-leczeniu-chorob-serca/